How Long Does Genicular Artery Embolization Last?

If you’re exploring genicular artery embolization (GAE) as a treatment for knee osteoarthritis, you likely have one big question: How long will it last?

It’s a great question we hear often at Pedes Orange County. When you’re considering a minimally invasive treatment like the GAE procedure for knees, understanding the durability of the relief it provides can help you decide if it’s the right option for you. In this post, we’ll cover what GAE is, how long you can expect it to last, and what factors can affect its results over time.

What Is Genicular Artery Embolization (GAE)?

GAE is a minimally invasive, image-guided procedure used to relieve chronic knee pain caused by osteoarthritis (OA). Osteoarthritis occurs when cartilage in the knee wears down, causing the bones to rub against each other and triggering an inflammatory response.

That inflammation brings increased blood flow to the lining of the knee (called the synovium), which results in more pain and swelling. GAE works by gently reducing blood flow to these inflamed vessels, calming the pain signals, and reducing inflammation in the process.

The best part? It’s done without surgery. No cutting, no general anesthesia, and often, no lengthy recovery time.

How Long Does GAE Last?

The relief from GAE is long-lasting for most patients, but, as with any medical treatment, results vary based on several factors. Here’s what studies and real-world experience have shown:

• Many patients report significant pain relief within the first 1 to 2 weeks
• Pain reduction continues to improve over the next few months
• In many cases, results can last 1 to 2 years or longer
• Some patients maintain relief for 3 years or more, especially when combined with healthy lifestyle habits

Because GAE addresses the underlying inflammation, not just the symptoms, many patients experience sustained relief, even after years of struggling with chronic pain.

What Do Clinical Studies Say?

Early research into GAE outcomes has been promising. While long-term studies are still ongoing, current data shows:

• Most patients experience 40–70% reduction in pain
• Improved function and mobility are reported across age groups
• Relief is sustained in the majority of patients for 12 to 24 months, with some needing a second procedure later on

Importantly, GAE has shown comparable results to more invasive treatments, such as surgery, without the risks or downtime typically associated with joint replacement.

Will I Need Another Procedure?

Yes, in some cases — but not always. For patients who respond well to GAE, relief can last years before additional treatment is considered. However, osteoarthritis is a progressive condition, which means that symptoms may eventually return as the joint continues to change.

If pain gradually returns, a repeat GAE may be considered, or your care team may explore additional options based on your overall joint health and goals.

Think of GAE as part of a long-term management plan, not just a one-time fix. The goal is to help you stay active, mobile, and pain-free for as long as possible, without jumping straight to surgery.

Factors That Affect How Long GAE Lasts

While most patients enjoy extended relief from GAE, several factors can influence how long the results last:

1. Severity of Osteoarthritis

GAE tends to be most effective for mild to moderate OA. If there’s advanced cartilage loss or bone-on-bone contact, relief may be shorter-lived.

2. Overall Health and Lifestyle

Maintaining a healthy weight, staying active, and practicing joint-friendly habits (like low-impact exercise and stretching) can help prolong the benefits of GAE.

3. Activity Level Post-Procedure

Overuse or returning to high-impact activities too soon may increase the likelihood of inflammation returning. Most patients benefit from a balanced rehab plan after GAE.

4. Underlying Inflammation

If systemic inflammation (from autoimmune conditions, for example) is present, this could contribute to recurrence and affect how long relief lasts.

Your care team at Pedes Orange County will consider these factors when creating a personalized plan for long-term joint health.

How Do I Know If GAE Is Wearing Off?

Everyone’s experience is different, but here are a few signs that relief may be fading:

• Gradual return of knee pain, especially with activity
• Stiffness or swelling that wasn’t present shortly after the procedure
• Increased need for over-the-counter pain medications
• Limitations in mobility or function that were previously improved

If you notice these changes, it doesn’t mean GAE “didn’t work.” It may simply be time for a follow-up evaluation or additional supportive care. In some cases, a second embolization can extend or restore relief.

Can GAE Be Repeated?

Yes. One of the benefits of genicular artery embolization is that it can be safely repeated if symptoms return. Repeat procedures are typically well-tolerated and can be just as effective as the first.

This flexibility gives you more control over your joint health, without committing to major surgery upfront.

Can GAE Delay or Avoid Knee Surgery?

Absolutely. Many patients use GAE as a way to delay or avoid total knee replacement, especially when they aren’t ready or eligible for surgery. It’s also a great option for those who:

• Can’t undergo general anesthesia
• Have underlying health conditions
• Want to avoid long recovery times
• Prefer to try a minimally invasive option first

Even if knee replacement is eventually needed, GAE can serve as a valuable bridge to reduce pain and maintain mobility in the meantime.

What Does Life Look Like After GAE?

For most patients, life after GAE includes:

• Reduced pain and stiffness
• Better range of motion
• Improved quality of life
• Confidence in managing osteoarthritis without surgery

Many people return to walking, biking, yoga, or even golf after GAE without needing daily pain meds or constant rest breaks. It’s a step forward, not just in pain relief but in regaining control of one’s everyday movement.

Is GAE Right for You?

GAE isn’t just about short-term relief — it’s about giving you longer-lasting results through a low-risk, low-pain procedure that’s high on comfort.

If you’re managing knee osteoarthritis and want to avoid the operating room, genicular artery embolization could be the right choice. At Pedes Orange County, we offer same-day or next-available consultations to help you explore your options and take the next step toward pain-free living. Contact us today to make an appointment with one of our vascular specialists. Let us help you feel better and stay better without surgery.