Peripheral artery disease is a subset disease of vascular disease, also referred to as peripheral arterial disease (PAD), which develops when excessive plaque buildup on the artery walls, causing narrowing of the arteries. The arteries deliver oxygen-rich blood from the heart to other parts of the body. When plaque builds up, it usually restricts the flow of blood, oxygen, and glucose. The obstruction causes pain in the leg as the muscles and tissues are starved for oxygen and other nutrients from the blood. While the pain usually occurs in your legs primarily, it can also be felt in other parts of the body, including your arms, stomach, hip, head, and kidneys.